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Probing the Power of Hepatocyte Regeneration to Treat Chronic Liver Disease

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While scientists have made significant strides in detailing the mechanisms of regeneration in healthy livers, less understood is what happens in an ailing liver. In chronic diseases such as MASH, hepatocytes are less able to regenerate as the illness progresses. One question is whether they lose the ability entirely or whether some process—such as fibrosis—is blocking their regenerative capacity. A Mount Sinai researcher is using mouse models of MASH to try to learn more.

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