Direct Reprogramming Induces Vascular Regeneration Post Muscle Ischemic Injury
In this study, researchers gauge the efficacy of a combinatory modRNA cocktail in directly reprogramming cardiac non-CMs during ischemic conditions. The team evaluated the benefits of partial reprogramming in the heart and skeletal muscle in vivo. This study demonstrates efficient, safe and controlled delivery of 7 genes that promotes cardiac protection and vascular regeneration post ischemic injury via a paracrine effect.